John R Hadcock: search on Z-Library

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1

Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs): Discovery of capromorelin

Philip A Carpino, Bruce A Lefker, Steven M Toler, Lydia C Pan, John R Hadcock, Ewell R Cook, Joseph N DiBrino, Anthony M Campeta, Shari L DeNinno, Kristin L Chidsey-Frink, William A Hada, John Inthavo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 219 KB

english, 2003

2

Potent and Selective, Sulfamide-Based Human β3-Adrenergic Receptor Agonists.

Robert L. Dow, Ernest S. Paight, Steven R. Schneider, John R. Hadcock, Diane M. Hargrove, Kelly A. Martin, Tristan S. Maurer, Nancy A. Nardone, David A. Tess, Paul DaSilva-Jardine

Journal:

Year:

2004

File:

PDF, 38 KB

2004

3

The biology of β-adrenergic receptors: Analysis in human epidermoid carcinoma A431 cells

Wang Hsien-Yu, Miguel Berrios, John R. Hadcock, Craig C. Malbon

Journal:

International Journal of Biochemistry

Year:

1991

Language:

english

File:

PDF, 2.07 MB

english, 1991

4

Potent and selective, sulfamide-based human β3-adrenergic receptor agonists

Robert L. Dow, Ernest S. Paight, Steven R. Schneider, John R. Hadcock, Diane M. Hargrove, Kelly A. Martin, Tristan S. Maurer, Nancy A. Nardone, David A. Tess, Paul DaSilva-Jardine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

5

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists

Philip A. Carpino, David A. Griffith, Subas Sakya, Robert L. Dow, Shawn C. Black, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Michael W. Fichtner, Colin R. Rose, Robert Day, Joseph Dibrino, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 194 KB

english, 2006

6

Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

Jennifer A. Lafontaine, Robert F. Day, Joe Dibrino, John R. Hadcock, Diane M. Hargrove, Michael Linhares, Kelly A. Martin, Tristan S. Maurer, Nancy A. Nardone, David A. Tess, Paul DaSilva-Jardine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

7

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles

Robert L. Dow, John R. Hadcock, Dennis O. Scott, Steven R. Schneider, Ernest S. Paight, Philip A. Iredale, Philip A. Carpino, David A. Griffith, Marlys Hammond, Paul DaSilva-Jardine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

8

Quantitativein vitroandin vivopharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) Receptor Antagonist

John R Hadcock, Philip A Carpino, Philip A Iredale, Robert L Dow, Denise Gautreau, Lucinda Thiede, Dawn Kelly-Sullivan, Jeffrey S Lizano, Xingrong Liu, Jeffrey Van Deusen, Karen M Ward, Rebecca E O'Co

Journal:

BMC Pharmacology

Year:

2010

Language:

english

File:

PDF, 900 KB

english, 2010

9

Discovery and biological characterization of capromorelin analogues with extended half-lives

Philip A. Carpino, Bruce A. Lefker, Steven M. Toler, Lydia C. Pan, John R. Hadcock, Marianne C. Murray, Ewell R. Cook, Joseph N. DiBrino, Shari L. DeNinno, Kristin L. Chidsey-Frink, William A. Hada, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

10

Agonist Regulation of Gene Expression of Adrenergic Receptors and G Proteins

John R. Hadcock, Craig C. Malbon

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

11

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

Dow, Robert L., Carpino, Philip A., Gautreau, Denise, Hadcock, John R., Iredale, Philip A., Kelly-Sullivan, Dawn, Lizano, Jeffrey S., O’Connor, Rebecca E., Schneider, Steven R., Scott, Dennis O.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 911 KB

english, 2012

12

Evidence that glucocorticoid response elements in the 5′-noncoding region of the hamster β2-adrenergic receptor gene are obligate for glucocoticoid regulation of receptor mRNA levels

Craig C. Malbon, John R. Hadcock

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 542 KB

english, 1988

13

Receptor density and cAMP accumulation: Analysis in CHO cells exhibiting stable expression of a cDNA that encodes the beta2-adrenergic receptor

Shaji T. George, Miguel Berrios, John R. Hadcock, Hsien-yu Wang, Craig C. Malbon

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 1.45 MB

english, 1988

14

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

Olivia Osborn, Manuel Sanchez-Alavez, Jeffrey S. Dubins, Alejandro Sanchez Gonzalez, Brad Morrison, John R. Hadcock, Tamas Bartfai

Journal:

Year:

2011

Language:

english

File:

PDF, 1.79 MB

english, 2011

15

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9 H -purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Griffith, David A., Hadcock, John R., Black, Shawn C., Iredale, Philip A., Carpino, Philip A., DaSilva-Jardine, Paul, Day, Robert, DiBrino, Joseph, Dow, Robert L., Landis, Margaret S., O’Connor, Rebec

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 145 KB

english, 2009

16

Regulation of receptor expression by agonists: transcriptional and post-transcriptional controls

John R. Hadcock, Craig C. Maibon

Journal:

Trends in Neurosciences

Year:

1991

Language:

english

File:

PDF, 923 KB

english, 1991

17

In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity

John R. Hadcock, David A. Griffith, Phillip A. Iredale, Phillip A. Carpino, Robert L. Dow, Shawn C. Black, Rebecca O’Connor, Denise Gautreau, Jeffrey S. Lizano, Karen Ward, Diane M. Hargrove, Dawn Kel

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 340 KB

english, 2010

18

Role of opiates and their receptors in the regulation of food intake and body weight

John R. Hadcock, Dennis O. Scott

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

19

Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin

Dubins, Jeffrey S., Sanchez-Alavez, Manuel, Zhukov, Victor, Sanchez-Gonzalez, Alejandro, Moroncini, Gianluca, Carvajal-Gonzalez, Santos, Hadcock, John R., Bartfai, Tamas, Conti, Bruno

Journal:

Year:

2012

Language:

english

File:

PDF, 772 KB

english, 2012

20

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2 H -pyrazolo[3,4- f ][1,4]oxazepin-8(5 H )-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Dow, Robert L., Carpino, Philip A., Hadcock, John R., Black, Shawn C., Iredale, Philip A., DaSilva-Jardine, Paul, Schneider, Steven R., Paight, Ernest S., Griffith, David A., Scott, Dennis O., O’Conno

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 191 KB

english, 2009

21

Down-Regulation of β -adrenergic Receptors: Agonist-Induced Reduction in Receptor mRNA Levels

John R. Hadcock and Craig C. Malbon

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 1004 KB

english, 1988

22

Regulation of β -adrenergic Receptors by ``Permissive'' Hormones: Glucocorticoids Increase Steady-State Levels of Receptor mRNA

John R. Hadcock and Craig C. Malbon

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 1.12 MB

english, 1988

23

TISSUE-SPECIFIC REGULATION OF α 1B , β 1 AND β 2 -ADRENERGIC RECEPTOR mRNAs BY THYROID STATE IN THE RAT

Lazar-Wesley, Eliane, Hadcock, John R., Malbon, Craig C., Kunos, George, Ishac, Edward J.N.

Journal:

Year:

1991

Language:

english

File:

PDF, 477 KB

english, 1991

24

Medieval Religious Houses, Ireland

John, Eric, Gwynn, Aubrey, Hadcock, R. Neville

Journal:

Year:

1972

Language:

english

File:

PDF, 245 KB

english, 1972

25

Somatostatin Acts by Inhibiting the Cyclic 3′,5′-Adenosine Monophosphate (cAMP)/Protein Kinase A Pathway, cAMP Response Element-Binding Protein (CREB) Phosphorylation, and CREB Transcription Potency

Tentler, John J., Hadcock, John R., Gutierrez-Hartmann, Arthur

Journal:

Molecular Endocrinology

Year:

1997

Language:

english

File:

PDF, 1.31 MB

english, 1997

26

SPIE Proceedings [SPIE SPIE's 1996 International Symposium on Optical Science, Engineering, and Instrumentation - Denver, CO (Sunday 4 August 1996)] Hyperspectral Remote Sensing and Applications - Spectrally and spatially adaptive hyperspectral data compression

Brower, Bernard V., Hadcock, David H., Reitz, Joseph P., Schott, John R., Shen, Sylvia S.

Year:

1996

Language:

english

File:

PDF, 645 KB

english, 1996

27

[Methods in Neurosciences] G Proteins Volume 29 || [10] Somatostatin receptor coupling to G proteins

Hadcock, John R.

Year:

1996

Language:

english

File:

PDF, 705 KB

english, 1996

28

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

Jones, Juli E., Cadena, Samuel M., Gong, Chenguang, Wang, Xiaomei, Chen, Zhiping, Wang, Sharon X., Vickers, Chad, Chen, Hong, Lach-Trifilieff, Estelle, Hadcock, John R., Glass, David J.

Journal:

Year:

2018

Language:

english

File:

PDF, 2.21 MB

english, 2018

29

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

Jones, Juli E., Cadena, Samuel M., Gong, Chenguang, Wang, Xiaomei, Chen, Zhiping, Wang, Sharon X., Vickers, Chad, Chen, Hong, Lach-Trifilieff, Estelle, Hadcock, John R., Glass, David J.

Journal:

Year:

2018

File:

PDF, 141 KB

2018

30

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

Bernardo, Barbara L., Wachtmann, Timothy S., Cosgrove, Patricia G., Kuhn, Max, Opsahl, Alan C., Judkins, Kyle M., Freeman, Thomas B., Hadcock, John R., LeBrasseur, Nathan K., Federici, Massimo

Journal:

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

31

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

Selimkhanov, Jangir, Thompson, W. Clayton, Patterson, Terrell A., Hadcock, John R., Scott, Dennis O., Maurer, Tristan S., Musante, Cynthia J., Adams, Michelle M.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016